Ferulic Acid Solubility Chart

myfunnyvalentine

262 posts · Joined 2011

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#2 · May 18, 2011

Does anyone know the solubility of FA in Butylene Glycol?

 

sophie4me

1,292 posts · Joined 2009

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#4 · May 18, 2011

This may be a silly question, but is butylene glycol and propylene glycol the same thing?

 

myfunnyvalentine

262 posts · Joined 2011

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#7 · May 18, 2011

I did some reading on Butylene Glycol vs Propylene Glycol:

Butylene glycol is the safest of a class of chemicals called solubilizers

Butylene Glycol:

Background: Glycolâ€2122s have extremely wide variations in toxicity that match their many applications in a variety of consumer products. Ethylene glycol is very well known as automobile anti-freeze. It is toxic upon ingestion, causing direct toxicity to erythrocytes [red blood cells]. Ethylene glycol is also teratogenic and a possible bone marrow depressant. The very similar propylene glycol has none of the same toxicity associated with ethylene glycol. In huge oral doses, propylene glycol can cause liver and kidney toxicity... Propylene glycol is both a skin irritant and a sensitizer.

Butylene glycol (1,4-butanediol) has none of the above toxicities. In fact there has been no documented organ-specific toxicity associated with 1,3-butanediol. Butanediol is also not a carcinogen.2 It is not a skin sensitizer, and is not considered a skin irritant.1 In undiluted form butylene glycol may irritate the eye and lining of the respiratory tract.

Some Consumer Advocates call butylene glycol an anti-freeze, and imply it is toxic because of its characterization as a glycol. Just about anything added to water is an anti-freeze. It is ludicrous then to label all anti-freeze formulations as toxic. Glycolâ€2122s can prevent water from freezing at 0 degrees Celsius. This fact does not make all glycolâ€2122s toxic, especially in the same manner and at the same levels of toxicity. Butylene glycol is present in several Neways products.

Safety concerns: Butylene glycol is rapidly absorbed through any tissue, including the skin. It is rapidly metabolized to gamma-hydroxybutyric acid in animals and humans. Gamma-hydroxybutyric acid is a naturally occurring chemical found in the brain and peripheral tissues of humans. Gamma-hydroxybutyric acid is also rapidly metabolized into succinate through the tricarboxylic acid cycle within the body. Given in high doses, a neuromodulator effect can be seen.4 However, in the small doses used as a solvent in pharmaceuticals and nutritionals, there are no known side effects. In water-based products, a concentration of 0.5% butylene glycol, as a solvent, would be safe for topical use.

Butylene glycol is the safest of

So if FA is soluble in Butylene Glycol, it seems far better than using Propylene glycol as a solvent.