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Glutathione / NAC May Abolish Depigmenting Effect
"The simultaneous administration of NAC, which up-
regulated glutathione content, completely abolished the depigmenting
potency of N-acetyl-4-S-CAP"
Frank Alena1, Walter Dixon1, Panakkezhum Thomas1 and Kowichi Jimbow1
This study examined the effect of glutathione on the in vivo
depigmenting potency of N-acetyl-4-S-cysteaminylphenol (N-acetyil-4-S-
CAP) in black and yellow mice after multiple intraperitoneal
injections on 10 consecutive days. In black mice (C57BL/6J, a/a), N-
acetyl-4-S-CAP showed dose-dependent depigmenting potency (0.5, 1.0,
and 2.0 mmol/kg), which was in parallel to the tissue eumelanin
content (98%, 28%, and 3% of controls, respectively) and to the
tissue glutathione content (94%, 85%, and 76%, respectively). In
lethal yellow mice (C57BL/6J, Ay/a), only a dose of 2.0 mmol/kg
showed the color change of hair to dark, not to white as seen in
black mice. This was reflected by the decrease of pheomelanin content
(56%) and the increase of eumelanin content (28% of black mice).
The
simultaneous administration of N-acetyl-cysteine, which increases glutathione content, completely abolished the depigmenting potency of
N-acetyl-4-S-CAP, whereas administration of buthionine sulfoximine,
which decreased the glutathione content, enhanced the
depigmenting potency of N-acetyh4-S-CAP in black hair.
In yellow
mice, the darkening of hair follicles by 2.O mmol/kg of N-acetyl-4-S-
CAP was completely abolished by the combined administration of N-
acetyl-cysteine, with the resulting hair color the same as in
controls, whereas combined administration with buthionine sulfoximine
caused some whitening of yellow hair follicles,
Our data indicate
that increase of glutathione reduces melanocytotoxicity (pigment destruction) and depigmenting potency of N-acetyl-4-S-CAP.
Skin | care | talk
"The simultaneous administration of NAC, which up-
regulated glutathione content, completely abolished the depigmenting
potency of N-acetyl-4-S-CAP"
Frank Alena1, Walter Dixon1, Panakkezhum Thomas1 and Kowichi Jimbow1
This study examined the effect of glutathione on the in vivo
depigmenting potency of N-acetyl-4-S-cysteaminylphenol (N-acetyil-4-S-
CAP) in black and yellow mice after multiple intraperitoneal
injections on 10 consecutive days. In black mice (C57BL/6J, a/a), N-
acetyl-4-S-CAP showed dose-dependent depigmenting potency (0.5, 1.0,
and 2.0 mmol/kg), which was in parallel to the tissue eumelanin
content (98%, 28%, and 3% of controls, respectively) and to the
tissue glutathione content (94%, 85%, and 76%, respectively). In
lethal yellow mice (C57BL/6J, Ay/a), only a dose of 2.0 mmol/kg
showed the color change of hair to dark, not to white as seen in
black mice. This was reflected by the decrease of pheomelanin content
(56%) and the increase of eumelanin content (28% of black mice).
The
simultaneous administration of N-acetyl-cysteine, which increases glutathione content, completely abolished the depigmenting potency of
N-acetyl-4-S-CAP, whereas administration of buthionine sulfoximine,
which decreased the glutathione content, enhanced the
depigmenting potency of N-acetyh4-S-CAP in black hair.
In yellow
mice, the darkening of hair follicles by 2.O mmol/kg of N-acetyl-4-S-
CAP was completely abolished by the combined administration of N-
acetyl-cysteine, with the resulting hair color the same as in
controls, whereas combined administration with buthionine sulfoximine
caused some whitening of yellow hair follicles,
Our data indicate
that increase of glutathione reduces melanocytotoxicity (pigment destruction) and depigmenting potency of N-acetyl-4-S-CAP.
Skin | care | talk