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Glutathione / NAC May Abolish Depigmenting Effect

"The simultaneous administration of NAC, which up-
regulated glutathione content, completely abolished the depigmenting
potency of N-acetyl-4-S-CAP"


Frank Alena1, Walter Dixon1, Panakkezhum Thomas1 and Kowichi Jimbow1

This study examined the effect of glutathione on the in vivo
depigmenting potency of N-acetyl-4-S-cysteaminylphenol (N-acetyil-4-S-
CAP) in black and yellow mice after multiple intraperitoneal
injections on 10 consecutive days. In black mice (C57BL/6J, a/a), N-
acetyl-4-S-CAP showed dose-dependent depigmenting potency (0.5, 1.0,
and 2.0 mmol/kg), which was in parallel to the tissue eumelanin
content (98%, 28%, and 3% of controls, respectively) and to the
tissue glutathione content (94%, 85%, and 76%, respectively). In
lethal yellow mice (C57BL/6J, Ay/a), only a dose of 2.0 mmol/kg
showed the color change of hair to dark, not to white as seen in
black mice. This was reflected by the decrease of pheomelanin content
(56%) and the increase of eumelanin content (28% of black mice).

The
simultaneous administration of N-acetyl-cysteine, which increases glutathione content, completely abolished the depigmenting potency of
N-acetyl-4-S-CAP, whereas administration of buthionine sulfoximine,
which decreased the glutathione content, enhanced the
depigmenting potency of N-acetyh4-S-CAP in black hair.

In yellow
mice, the darkening of hair follicles by 2.O mmol/kg of N-acetyl-4-S-
CAP was completely abolished by the combined administration of N-
acetyl-cysteine, with the resulting hair color the same as in
controls, whereas combined administration with buthionine sulfoximine
caused some whitening of yellow hair follicles,

Our data indicate
that increase of glutathione reduces melanocytotoxicity (pigment destruction) and depigmenting potency of N-acetyl-4-S-CAP.



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THanks LNL. I'd seen this original research myself BUT forgot where the heck I found it B4 I could post a link to it.
 

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Glutathione / NAC May Abolish Depigmenting Effect

"The simultaneous administration of NAC, which up-
regulated glutathione content, completely abolished the depigmenting
potency of N-acetyl-4-S-CAP"


Frank Alena1, Walter Dixon1, Panakkezhum Thomas1 and Kowichi Jimbow1

This study examined the effect of glutathione on the in vivo
depigmenting potency of N-acetyl-4-S-cysteaminylphenol (N-acetyil-4-S-
CAP) in black and yellow mice after multiple intraperitoneal
injections on 10 consecutive days. In black mice (C57BL/6J, a/a), N-
acetyl-4-S-CAP showed dose-dependent depigmenting potency (0.5, 1.0,
and 2.0 mmol/kg), which was in parallel to the tissue eumelanin
content (98%, 28%, and 3% of controls, respectively) and to the
tissue glutathione content (94%, 85%, and 76%, respectively). In
lethal yellow mice (C57BL/6J, Ay/a), only a dose of 2.0 mmol/kg
showed the color change of hair to dark, not to white as seen in
black mice. This was reflected by the decrease of pheomelanin content
(56%) and the increase of eumelanin content (28% of black mice).

The
simultaneous administration of N-acetyl-cysteine, which increases glutathione content, completely abolished the depigmenting potency of
N-acetyl-4-S-CAP, whereas administration of buthionine sulfoximine,
which decreased the glutathione content, enhanced the
depigmenting potency of N-acetyh4-S-CAP in black hair.

In yellow
mice, the darkening of hair follicles by 2.O mmol/kg of N-acetyl-4-S-
CAP was completely abolished by the combined administration of N-
acetyl-cysteine, with the resulting hair color the same as in
controls, whereas combined administration with buthionine sulfoximine
caused some whitening of yellow hair follicles,

Our data indicate
that increase of glutathione reduces melanocytotoxicity (pigment destruction) and depigmenting potency of N-acetyl-4-S-CAP.
Thank you, LNL. Very informative.

I would only add that the study speaks to the negating effects of glutathione on this agent (NAC) only, which is a relatively new depigmenting agent. A cardinal rule of scientific research is that one must be careful to not generalize one effect to be all-inclusive to other entities.

For example, if a product were only tested on a certain skin type say, "oily skin," the effects cannot be generalized or said to be a "true" result for all skin types, for example, ("combination skin, dry skin").

Sometimes I get caught up in my science-ese so I hope I am clear.

I am simply saying that while there was an "effect" for NAC in this study, but it does not necessarily imply an "effect" for say, HQ, Arbutin, Alzeic Acid, Monobenzone, Licorice Extract, Lemon Juice...etc.

Love you guys, and keep up the good work with responsible, respectful, informative, humanistic, healthy, and caring posts!

Crescent!
 

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Hello, I can confirm this study. I used of Mequinol+RA and I believed that I went light up about3 tones if I did injections of Glutathion. It cancelled all the effects of Mequinol RA. I became dark in a short time. I afterward used a product which contains cysteine and I continued to darken.

Glutathione / NAC May Abolish Depigmenting Effect

"The simultaneous administration of NAC, which up-
regulated glutathione content, completely abolished the depigmenting
potency of N-acetyl-4-S-CAP"


Frank Alena1, Walter Dixon1, Panakkezhum Thomas1 and Kowichi Jimbow1

This study examined the effect of glutathione on the in vivo
depigmenting potency of N-acetyl-4-S-cysteaminylphenol (N-acetyil-4-S-
CAP) in black and yellow mice after multiple intraperitoneal
injections on 10 consecutive days. In black mice (C57BL/6J, a/a), N-
acetyl-4-S-CAP showed dose-dependent depigmenting potency (0.5, 1.0,
and 2.0 mmol/kg), which was in parallel to the tissue eumelanin
content (98%, 28%, and 3% of controls, respectively) and to the
tissue glutathione content (94%, 85%, and 76%, respectively). In
lethal yellow mice (C57BL/6J, Ay/a), only a dose of 2.0 mmol/kg
showed the color change of hair to dark, not to white as seen in
black mice. This was reflected by the decrease of pheomelanin content
(56%) and the increase of eumelanin content (28% of black mice).

The
simultaneous administration of N-acetyl-cysteine, which increases glutathione content, completely abolished the depigmenting potency of
N-acetyl-4-S-CAP, whereas administration of buthionine sulfoximine,
which decreased the glutathione content, enhanced the
depigmenting potency of N-acetyh4-S-CAP in black hair.

In yellow
mice, the darkening of hair follicles by 2.O mmol/kg of N-acetyl-4-S-
CAP was completely abolished by the combined administration of N-
acetyl-cysteine, with the resulting hair color the same as in
controls, whereas combined administration with buthionine sulfoximine
caused some whitening of yellow hair follicles,

Our data indicate
that increase of glutathione reduces melanocytotoxicity (pigment destruction) and depigmenting potency of N-acetyl-4-S-CAP.
 

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people just seem to WANT to believe that they can achieve short cut skin lightening by gobbling handfuls of gluta. pills or getting injections. Verry frustrating! Typically, some person posts a study about glutathione BUT conveniently omits the part about how it was NOT administered to any living human being in the form of a pill, injectible or topical treatment! A lot of things can be made to occur in a lab in a petri dish.

People need to think a little:Glutathione also plays a critical role in melanin formation. Both HQ & RA help SUPPRESS glutathione as a part of their role in reducing melanin production. It drives me bananas when misinformation gets deliberately spread here. Too many people act right away on what they read w/o bothering to check.

Following 'Gluta-logic', we ought to be able to get some iron filings & inject them directly into our bloodstreams: iron is good for us, right??? Our blood needs it, right??? Why not just rub it all over our skin & add some calcium too while we're at it!!!
 

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sorry if i sound ignorant..but what is NAC? and so does this mean glutathione tablets r useless when it comes to lightening? i just bought a bottle
 

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this doesn't make sense to me. in seems they are referring to hair follicles rather than skin. the article karan posted makes more sense.
 
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