I had read that some diabetes meds help stimulate seb glands and invigorate skin moisture and oil systems via the PPARs. I assumed these were all internal medications, but I just found out that there are actually topical PPAR stimulators (GW1514 for example).
my damage from accutane is basically isolated to my face, so obviously a topical treatment is appealing since i can just apply it to the affeat areas.
However, I feel like I've mentioned PPAR stimulators to my dermatologist before, yet he sort of shook his head. He has an MD and a PHD, so I can't really question him, but at the time i was under the impression that PPAR stims were internal....but topical seems less severe/risky?
Does anyone know why PPAR stims havent been uses for skin conditions much? what are the downfalls?
I took accutane 5 years ago and have permanent damage: Now my face has skin fragility and thinness, extreme dryness and wrinkling, inflammation and irritation, dyshesion and diminished waterproofing, as the skin barrier homeostasis has been disrupted, etc. etc.
about 1 year ago i started taking adderall for adhd. and this has made my skin condition worse. i dont want to downplay how adderall has worsened my skin....but I have a classmate that I see who takes about 10 times my dose and is about 60 pounds lighter than me yet doesnt have skin issues remotely as bad as mine.
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR.
Department of Medicine, University of California, San Francisco, California, USA.
Erratum in:
J Invest Dermatol. 2004 Oct;123(4):806.
Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-alpha activation stimulates keratinocyte differentiation in vitro and in vivo, is anti-inflammatory, and improves barrier homeostasis. Recent studies have shown that PPAR-beta/delta activation induces keratinocyte differentiation in vitro. This study demonstrated that topical treatment of mice with a selective PPAR-beta/delta agonist (GW1514) in vivo had pro-differentiating effects, was anti-inflammatory, improved barrier homeostasis, and stimulated differentiation in a disease model of epidermal hyperproliferation [corrected]. In contrast to PPAR-alpha activation, PPAR-beta/deltain vivo did not display anti-proliferative or pro-apoptotic effects. The pro-differentiating effects persisted in mice lacking PPAR-alpha, but were decreased in mice deficient in retinoid X receptor-alpha, the major heterodimerization partner of PPAR. Furthermore, in vitro PPAR-beta/delta activation, aside from stimulating differentiation-related genes, additionally induced adipose differentiation-related protein (ADRP) and fasting induced adipose factor (FIAF) mRNA in cultures keratinocytes, which was paralleled by increased oil red O staining indicative of lipid accumulation, the bulk of which were triglycerides (TG). Comparison of differentially expressed genes between PPAR-beta/delta and PPAR-alpha activation revealed distinct profiles. Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes.
my damage from accutane is basically isolated to my face, so obviously a topical treatment is appealing since i can just apply it to the affeat areas.
However, I feel like I've mentioned PPAR stimulators to my dermatologist before, yet he sort of shook his head. He has an MD and a PHD, so I can't really question him, but at the time i was under the impression that PPAR stims were internal....but topical seems less severe/risky?
Does anyone know why PPAR stims havent been uses for skin conditions much? what are the downfalls?
I took accutane 5 years ago and have permanent damage: Now my face has skin fragility and thinness, extreme dryness and wrinkling, inflammation and irritation, dyshesion and diminished waterproofing, as the skin barrier homeostasis has been disrupted, etc. etc.
about 1 year ago i started taking adderall for adhd. and this has made my skin condition worse. i dont want to downplay how adderall has worsened my skin....but I have a classmate that I see who takes about 10 times my dose and is about 60 pounds lighter than me yet doesnt have skin issues remotely as bad as mine.
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR.
Department of Medicine, University of California, San Francisco, California, USA.
Erratum in:
J Invest Dermatol. 2004 Oct;123(4):806.
Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-alpha activation stimulates keratinocyte differentiation in vitro and in vivo, is anti-inflammatory, and improves barrier homeostasis. Recent studies have shown that PPAR-beta/delta activation induces keratinocyte differentiation in vitro. This study demonstrated that topical treatment of mice with a selective PPAR-beta/delta agonist (GW1514) in vivo had pro-differentiating effects, was anti-inflammatory, improved barrier homeostasis, and stimulated differentiation in a disease model of epidermal hyperproliferation [corrected]. In contrast to PPAR-alpha activation, PPAR-beta/deltain vivo did not display anti-proliferative or pro-apoptotic effects. The pro-differentiating effects persisted in mice lacking PPAR-alpha, but were decreased in mice deficient in retinoid X receptor-alpha, the major heterodimerization partner of PPAR. Furthermore, in vitro PPAR-beta/delta activation, aside from stimulating differentiation-related genes, additionally induced adipose differentiation-related protein (ADRP) and fasting induced adipose factor (FIAF) mRNA in cultures keratinocytes, which was paralleled by increased oil red O staining indicative of lipid accumulation, the bulk of which were triglycerides (TG). Comparison of differentially expressed genes between PPAR-beta/delta and PPAR-alpha activation revealed distinct profiles. Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes.