[Temarinette]

Ahh, this post pulled me out from my lurker mode lol. I know this one. Even tried it. Got it from a friend. It made me very light, more than glutathione shots did. They are very expensive tho. Couldn't keep up.

 

[Temarinette]

Where did you get them from? Any negative side effects experienced? How long did you take them for?

I got them from a seller in Paris ( France).
I tried it after after a long time friend went very light ( she was lupita Nyongo dark and became like Jasmine Sanders in like 6 months?).

It is not one pill though, but rather a mix of pills.
I took it for 4 months. Side effects, it decreased my appetite and I had some white and blond body hairs randomly on my body but i didn’t mind.
I'm not not too good with estimating shades. Let's say I was brown like a young Gabrielle Union and lightened to a light Rihanna shade ( or like our beloved football player Killian Mbappe).

As i said, it is pretty expensive, at least for me ( I paid like 500€/month). The result was worth it. And when I stopped it took some time to darken and even, I didn't return to my former complexion. The seller said that it was cutting off the melanin production hence the fast lightening.
I searched for a cheaper option on the internet but couldn't find anything lol.

I don't know if this is this exact product the American celebrities are using but the results was fabulous.
I'm sure it is not glutathione alone that lighten the celebrities skin, I've used glutathione for many years on and off and although I got light, it wasn't dramatic ( went from NW50 to NC45 maximum) and I had the impression that i hit a plateau at some time. Had to use topicals to get a more pronounced lightening.
I imagine, they have a regimen easy to follow and many celebrities drink, do drugs or other questionable substances and always partying and it is not compatible with glutathione use ( I had to stop smoking in order for my glutathione regimen to work).

I will try to find some before after pics to post here from my slc pills era.

 

[Temarinette]

They use skin whitening pills like SLC i knew it lately

Do you use it yourself?

 

[Temarinette]

What’s the full meaning of SLC please? Can’t seem to find much info on it

Hi Kweeny.

It stands for SLC24A5, it's one of the genes responsible for the production of melanin in the body.
The slc pills I think inhibit this gene.
I think there a south Asian brand that sell it ( or something similar) but in injections form.

 

[Temarinette]

What was the effect on hard to lighten areas such as knuckles / joints and the feet? Were the tablets successful in blending those areas naturally ?

My body lightened evenly without any issues. To be honest, I never had a knuckles or feet ,joints issues as I never use strong topicals so and never had any issues either to lighten these parts even before. But it lightened my butt lol which is something glutathione never did for me

Here are my pictures from using the slc pills after around 3 months . Will probably delete later. I included a pic I took with my hands

 

[Temarinette]

What was the effect on hard to lighten areas such as knuckles / joints and the feet? Were the tablets successful in blending those areas naturally ?

My

I’m at my goal but I would love to use this in maintenance mode, a few times a week as opposed to daily. That would also be lighter on the pockets as it would last longer 😉. Please check your DM , I have sent you a message.

Whatever inside out product you use, I don't think you can start directly with maintenance mode as the product needs to build up in your organism before in order to be able to be maintained afterwards, IMO.

Will check DM.

 

[Temarinette]

My sister did not have any troubles with them, she is on it for a while and i am taking them for almost 4 weeks without side effects
But my pocket hurts its expensive and i hope to quickly arrive at my desired shade to go in maintenance mode

I think that in France its getting known little by little, but people are so secret with their routine.
My sister really had to dig to find this product



Hahahaha same here unfortunately, can you please check your dms i want to ask you if its the same supplier that you had

Lol, people are so secretive with their lightening regimen, like it's some gold. Never understood it. Unfortunately, those celebrities will never share their real regimen with their fans as they probably want the only ones to shine and get the praise. Smh.

How are your results so far?
Will check your DM.

 

[Temarinette]

Many thanks...
Seems like the future, could be readily available to all

I hope so , but maybe it's too controversial to become popular? I already see the hate for glutathione.

 

[Temarinette]

You


Thank you for sharing. You look absolutely beautiful!! 💕💕💕💕
Do the tablets contain Gluthatione at all? I’m trying to figure out how they work and with which chemical.

Thank you. Will resume the regimen in January, hopefully I can get lighten more.
It doesn't contain glutathione. It's an enzyme called SirNA5 that cut off the melanin production before it is even produced.

 

[Temarinette]

I saw in her Instagram that she is pregnant and I also wondered how she’ll maintain.

Getting this light in 3 years is pretty reasonable imo.

Could be just glutathione shots. Tutsis Rwandese women ( same for the indian and peulhs women ) can be dark skinned but their melanin is very diluted and not very concentrated. This kind of complexion react very well to glutathione ( or even mild topical lighteners) as there isn't that much work to begin.

And glutathione can be used during pregnancy. Watch out for the complexion of her baby when she gives birth. If the baby is very light skinned ( beyond normal), that would mean it's probably glutathione she is using. If the baby is dark skinned like mom and dad, then she is using probably mild topicals.

 

[Temarinette]

I have been looking across the internet for more research on this gene and I can’t seem to find it at all . If anyone finds any clinical studies please post them here. I always like to do in depth research before purchasing a new product .

Are you sure you don't find anything?

Here is the website i came across many years ago (2018-2019) when i was looking for glutathione alternative.

https://29nexentury.sg/pdf/SLC24A5_III_eng.pdf

I checked on google and found some studies like these ones

Repression of Slc24a5 can reduce pigmentation in chicken - PubMed

Slc24a5 is a putative cation transporter, which is a member of the potassium-dependent sodium-calcium ion exchanger family. Association of the Slc24a5 gene with pigmentation has been established in Zebrafish, mice and humans. Despite these findings, its function in chicken remains unknown. The...

pubmed.ncbi.nlm.nih.gov

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans - PubMed

Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5...

pubmed.ncbi.nlm.nih.gov

Type keywords "SLC24A5 melanin or melanogenesis.
They didn't exact name of the said inhibitor but at least, the process seemed legit. I wanted to try but the product is sold apparently only in Asia and most stores were not in english , i wasn't comfortable buying in an unknown currency. so i backed off.

Now this year i learned about the slc pills and when researching i found out that the main ingredient enzyme SirNA-5 was the one inhibiting this SLC24A5 gene.
If you type the keywords "SiRNA-5 melanin" on google or duckduckgo, you will find many results. Here are some:

Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes - PubMed

Tyrosinase (TYR) plays a critical role in cellular melanogenesis and, thus, has been the major target of pharmacological approaches for the control of skin pigmentation. This study examined an alternative molecular approach using TYR-small interfering RNA (siRNA) to control melanogenesis in the...

pubmed.ncbi.nlm.nih.gov

US20140336371A1 - Sirna molecule for inhibiting growth of melanin and application thereof - Google Patents

Provided is a double-chain siRNA molecule targeting a microphthalmia-associated transcription factor MITF coding gene. A sense strand of the siRNA molecule has a sequence of SEQ ID NO: 3 and an anti-sense strand has a sequence of SEQ ID NO: 4, and the anti-sense strand specifically binds to mRNA...

patents.google.com

siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis - PubMed

Cyclooxygenase-2 (COX-2) is an enzyme induced in response to multiple mitogenic and inflammatory stimuli, including UV light. UV-induced COX-2 expression induces production of prostaglandin E2 (PGE2) in keratinocytes, which mediates inflammation and cell proliferation. Until recently, studies...

pubmed.ncbi.nlm.nih.gov

There are many products like this one that are not popular or even known in western countries. But if you dig into the asian google you can find some good stuffs sometimes.
Asian researchers are way more advanced in the subject than their western counterparts and i doubt it will ever be FDA approved. Heck, the FDA even removed its approbation for NAC despite its numerous benefits. Thankfully i don't live in the US and here we still have access to many products.

 

[Temarinette]

I am keen on finding a peer reviewed study on this but nothing as of yet is online.
We can surmise that this is a synthetic form of the gene so maybe it isn’t FDA approved yet?

In the meantime , users please continue to update us.

Also do you not have the fear of waking up porcelain white while using this?😂😂😂

I just posted some documents i found.

Also, no i'm not afraid to become porcelaine white lol. The process is very gradual and as soon as i hit my goal i will go into maintenance mode. That said, complexion dysmorphia is really a thing because even when i became very light with the product, i still saw myself dark when looking in the mirror and i kept pushing. Its only when i did some pictures comparisons i saw that i had passed my initial goal since at least one month.
I understand why some girls become too white , you don't see yourself lightening. Your eyes get used to your complexion pretty quickly. Just like when you lose weight and you still see yourself overweight.

Anyway, to get back to the theme of the thread, there are many not mainstream actives that can be used to lighten their skin without having to rub creams or glutathione only ( i love glutathion and still use it for anti aging and health purposes but i doubt it can turn a very dark person in Grety Riverson).

 

[Temarinette]

Actually glutathione CAN increase chances of complications. There's differing opinions on glutathione for pregnant women because it has been shown to cause complications to some (like miscarriage) and also has protective properties for mother and baby. Its a risk not even worth taking and because of that, doctors generally would not advise it as there is no clear understanding.
In addition, i don't believe in gluta IV - Its a gimick which does not have proper scientific backing to whitening the skin, people who do it ALWAYS use topicals also. Its easier to work on people who are already pale to begin with (like kojic acid). I wish we could dead the concept of gluta IV for whitening dark skin. Scientifically, it should but in reality...it really doesn't lol. Great for the immune system though.

I think you're right tho...3 years to get this light is so doable and i'm sure she's using something mild. I'm just wondering what it is because I'm planning to get pregnant in the next year and maannnn that pregnancy PIH...God forbid.

I know some physicians don't recommend glutathione but I have some acquaintances who used glutathione during their pregnancies with no issue and getting light babies and they got no pregnancy mask. So it might be a good idea if the dosage is not too high. After all, glutathione is found in great quantity in vegetables. To forbid glutathione during pregnancy would like saying don't eat vegetables during your pregnancy. I think it's all about the dosage.

The real danger is the vitamin C dosage while taking glutathione. Vitamin C in high dosage is bad during pregnancy. Better stay under 1000 mg or it can trigger complications.



That said, I agree with you that glutathione IV is overrated. The dosage and frequency is not enough to lighten the skin unless once again the user is already light or diluted melanin.

The only glutathione IV I had success with had in its ingredient list a melanin inhibitor. Otherwise, glutathione suppositories worked best. It's more about the repetition than the dosage.

 

[Temarinette]

Hi! I've been lurking on and off on sct since 2017, finally decided to join the community after taking interest on this topic.




You said you went from young Gabrielle Union to a light Rihanna shade and never returned to your former shade, I'm curious to ask what shade did your skin stop at after discontinuing the pills?



Also, thank you Temarinette and Michoco for sharing this information about SLC pills! Had you not mentioned it, I and a lot of others still wouldn't know about them.

I'm sorry, I think I used the wrong words. Bear with me. English is not my first language.

I darkened after I stopped using it. Just I didn't went back to my original complexion. It's like, my melanin became diluted or something like that. It wasn't as dense as when I started using the pills. That said right I'm just using glutathione and my complexion is in between. I don't lighten but I don't darken either. It does help I think.

You re welcome. Thanks to Michoco who brought out the subject. I wanted previously to start a thread about it but I know how SCT can be sometimes with new products so I was waiting that someone else mentions it to chime in lol.

 

[Temarinette]

Your english is perfect! I understood clearly what you meant in your original post. I think it was me who was not clear enough by what I meant. I was trying to ask what your current complexion is right now since you've mentioned how you've redarkened but didn't go back to your original tone.

Oh OK, no worry.
Here are again my pictures. First one is i how I looked before last July. The middle one is the max I got. It was in October, i stopped by then. The right one is how I look now in december.

 

[Temarinette]

I am a bit worried about “ it’s method of operation”
It’s a synthetic gene, to simplify things so I am just wondering if it may impact other genetic “ materials “ since the skin literally covers the entire body.
What I am saying is there are documents online that tell us what it is but no studies have been carried out , no side effects recorded, what to expect in the next 5 years etc

See skin lightening is generally risky but anything that alters my gene......

PS - this is my opinion and I genuinely appreciate everyone sharing information about SLC

Hello Kweeny, I appreciate your input and understand your concern. This is a really interesting point you bring up.
But I don't think it alters the gene, alteration of a gene is irreversible and definitive and is in the same field of gene therapy. It is a reversible inhibitor and is excreted in few hours by the urine.
Just like many other lighteners out there that inhibit either enzymes or hormones in the body.

Lighteners have several ways of targeting the melanin like inhibition of tyrosinase or alpha msh or of many other enzymes/hormones.

These targets usually have many other functions in the organism than just fabricating melanin. That doesn't stop people from using them.
Alpha msh for exemple is involved in neuroimmune processes, mood control ( deficit of alpha msh is linked to anxiety, alzheimer, depression, sleep and appetite control.
Tyrosinase is involved in wound healing, and some other neuro processes).

The thing is anything that lightens your skin from the outside or inside out is inhibiting something.
So this active is no worse than another one ( im more afraid of topical products containing steroids or mercury that can harm the immediate health over the short and long term by accumulation in the tissues). It just has another target.
As long as the effects are reversible, for me , I'm okay with it. And this peptide is inhibiting a gene that is only coding melanin which for me is pretty fantastic because that means that unlike many other agents, it doesn't interfere with other mechanisms.

I find rather fascinating that everyday are discovered new ways of targeting melanin.

The thread is about what could the celebrities use for their skin, and this product fits well ( whether or not one is okay with it).

And I also understand why most of the times, celebrities are secretive of their regimens.
Some have probably access to products that will never be FDA approved, nor accepted by the general public. Because it could be so controversial, and attract a negative attention.

That said, it's important ( and I agree with you on this point) that people should have all informations to make their informed choice and I hope that maybe in the future we see more studies about this product and even about other new exciting ones.

Happy lightening everyone and also merry Christmas to y'all.

 

[Temarinette]

Thank you for highlighting this.
I am not really interested in this SLC whitening capsule, as I don’t know enough about the contents of it.
I prefer to stick to my Acetyl Gluthatione and Liposomal Vitamin C, which I get from a verified pharmacy.

It's okay to use glutathione but this is not in a pharmacy even "verified" that you will get a dosage of acetyl glutathione that will lighten your black skin. I don't know what is your goal though.
If it's just to lose 1/2 shade and some slight glow,it's okay added with some exfoliation.

But if you want more, you need at least 2000 mg/day to get a results if you are black and I don't know any pharmacy that sell 1000 mg/2000 mg dosage.
Why do black girls want to lighten their skin with white people dosages and/or methods?
These products usually are not designed for our skins that contain way more melanin than theirs.

I've seen Caucasian girls becoming pale white with only 200 mg of glutathione by IV , and South asian girls with 600 mg, but for black skins you need at least 2000-2400 mg, preferably 3000 mg.

If some black person says they are getting results with a very small dosage of glutathione, you can bet they are rubbing some cream and using soap along with the glutathione thinking they just help the glutathione but in fact it's the cream/soap doing all the work.

I used acetyl glutathione for 9 months and got results but it was 2000 mg at first, then 4000 mg/day. I bought 1 kg off alibaba and did my own capsules. Under 2000 mg was useless.
Plus acetyl glutathione is a very sensitive antioxidant. It reacts negatively at any chemical. I even had to change my soap because it wouldn't work with sodium laureth sulfate. Couldn't drink alcohol or use certain supplements, and If i had a bad night, my skin would be dull the day after.
And the cherry on the cake, I lost all my results in just 2 weeks of vacation in Africa and came back darker then ever.
If I want to compare, L glutathione is a better lightener than S acetyl glutathione because it is less sensitive and the results are more pronounced and stable.

Go for glutathione, but if you want to see results, you need to do it the right way otherwise, it's just a waste of money.

 

[Temarinette]

View attachment 68139

Hey ladies, what’s your take on this supplement. After finding out about the SLC, I started doing research and found this:

Sodium/potassium/calcium exchanger 5 (NCKX5), also known as solute carrier family 24 member 5 (SLC24A5), is a protein that in humans is encoded by the SLC24A5 genethat has a major influence on natural skin colour variation.

Would love to know your thoughts 💭

Ah great find. But this is not what I've used although they described perfectly the how it does work. The packaging is nice too.

I have to add many good products, you won't find them on internet. Some are , some are not. Doesn't mean they are not good.
The best cream I've ever used was done by some auntie in my church who didn't even know how to use internet. The complexion it gave me was out of this world. After she stopped making creams , I tried many brands or mixes on online stores but never got the same results.

Same for glutathione IV, the brand that gave me the best results was sold by a French seller by words of mouth. And it was frequently out of stock. Tried 3 other brands (Glutax, Venisci and another brand i don't remember the name, it was a reputable brand but the liquid was pink and it gaves me rashes ) after that but same, it didn't work as good as this one.

 

[Temarinette]

Thank you for the response. I’ve inboxes you hun, I hope you saw it. Did you know what the auntie from church mixed & also the brand glutathione iv

No, must have missed it .Let me check out my PM.

And for the auntie, no, nobody knew what she was using. Just that it worked and smelled good like cocoa butter. It gave a high yellow complexion with a yellow undertone. No knuckles, everything was even from head to toe.
She said it was all natural lol but it's not possible because of the fast results it provided . I know she was mixing some serums because when she discontinued the cream, she said (she forgot her own narrative) that the serums she were using had been discontinued by the manufacturers. So unfortunately I will never know. Now that I think of it, I knew where she lived, I should had go by night checking her dumpster outside her house to find the empty bottles she was mixing with ha ha. Talk about craziness.

And for the glutathione brand , the name was MKR advanced skin therapy. It wasn't sold on internet ( especially since glutathione injections are forbidden in the EU for skin whitening purpose).