[Betterfly]

I would love to learn more specifics on obtaining this as well!

 

[Beleza Carioca]

Hi Kweeny.

It stands for SLC24A5, it's one of the genes responsible for the production of melanin in the body.
The slc pills I think inhibit this gene.
I think there a south Asian brand that sell it ( or something similar) but in injections form.

I have been looking across the internet for more research on this gene and I can’t seem to find it at all . If anyone finds any clinical studies please post them here. I always like to do in depth research before purchasing a new product .

 

[kweeny]

I am keen on finding a peer reviewed study on this but nothing as of yet is online.
We can surmise that this is a synthetic form of the gene so maybe it isn’t FDA approved yet?

In the meantime , users please continue to update us.

Also do you not have the fear of waking up porcelain white while using this?😂😂😂

 

[kweeny]

I hope so , but maybe it's too controversial to become popular? I already see the hate for glutathione.

So true and that’s despite glutathione having tons of health benefits. People fail to see the good in certain things as soon as it’s is linked to skin lightening

 

[Temarinette]

I have been looking across the internet for more research on this gene and I can’t seem to find it at all . If anyone finds any clinical studies please post them here. I always like to do in depth research before purchasing a new product .

Are you sure you don't find anything?

Here is the website i came across many years ago (2018-2019) when i was looking for glutathione alternative.

https://29nexentury.sg/pdf/SLC24A5_III_eng.pdf

I checked on google and found some studies like these ones

Repression of Slc24a5 can reduce pigmentation in chicken - PubMed

Slc24a5 is a putative cation transporter, which is a member of the potassium-dependent sodium-calcium ion exchanger family. Association of the Slc24a5 gene with pigmentation has been established in Zebrafish, mice and humans. Despite these findings, its function in chicken remains unknown. The...

pubmed.ncbi.nlm.nih.gov

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans - PubMed

Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5...

pubmed.ncbi.nlm.nih.gov

Type keywords "SLC24A5 melanin or melanogenesis.
They didn't exact name of the said inhibitor but at least, the process seemed legit. I wanted to try but the product is sold apparently only in Asia and most stores were not in english , i wasn't comfortable buying in an unknown currency. so i backed off.

Now this year i learned about the slc pills and when researching i found out that the main ingredient enzyme SirNA-5 was the one inhibiting this SLC24A5 gene.
If you type the keywords "SiRNA-5 melanin" on google or duckduckgo, you will find many results. Here are some:

Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes - PubMed

Tyrosinase (TYR) plays a critical role in cellular melanogenesis and, thus, has been the major target of pharmacological approaches for the control of skin pigmentation. This study examined an alternative molecular approach using TYR-small interfering RNA (siRNA) to control melanogenesis in the...

pubmed.ncbi.nlm.nih.gov

US20140336371A1 - Sirna molecule for inhibiting growth of melanin and application thereof - Google Patents

Provided is a double-chain siRNA molecule targeting a microphthalmia-associated transcription factor MITF coding gene. A sense strand of the siRNA molecule has a sequence of SEQ ID NO: 3 and an anti-sense strand has a sequence of SEQ ID NO: 4, and the anti-sense strand specifically binds to mRNA...

patents.google.com

siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis - PubMed

Cyclooxygenase-2 (COX-2) is an enzyme induced in response to multiple mitogenic and inflammatory stimuli, including UV light. UV-induced COX-2 expression induces production of prostaglandin E2 (PGE2) in keratinocytes, which mediates inflammation and cell proliferation. Until recently, studies...

pubmed.ncbi.nlm.nih.gov

There are many products like this one that are not popular or even known in western countries. But if you dig into the asian google you can find some good stuffs sometimes.
Asian researchers are way more advanced in the subject than their western counterparts and i doubt it will ever be FDA approved. Heck, the FDA even removed its approbation for NAC despite its numerous benefits. Thankfully i don't live in the US and here we still have access to many products.

 

[Temarinette]

I am keen on finding a peer reviewed study on this but nothing as of yet is online.
We can surmise that this is a synthetic form of the gene so maybe it isn’t FDA approved yet?

In the meantime , users please continue to update us.

Also do you not have the fear of waking up porcelain white while using this?😂😂😂

I just posted some documents i found.

Also, no i'm not afraid to become porcelaine white lol. The process is very gradual and as soon as i hit my goal i will go into maintenance mode. That said, complexion dysmorphia is really a thing because even when i became very light with the product, i still saw myself dark when looking in the mirror and i kept pushing. Its only when i did some pictures comparisons i saw that i had passed my initial goal since at least one month.
I understand why some girls become too white , you don't see yourself lightening. Your eyes get used to your complexion pretty quickly. Just like when you lose weight and you still see yourself overweight.

Anyway, to get back to the theme of the thread, there are many not mainstream actives that can be used to lighten their skin without having to rub creams or glutathione only ( i love glutathion and still use it for anti aging and health purposes but i doubt it can turn a very dark person in Grety Riverson).

 

[Beleza Carioca]

Are you sure you don't find anything?

Here is the website i came across many years ago (2018-2019) when i was looking for glutathione alternative.

https://29nexentury.sg/pdf/SLC24A5_III_eng.pdf

I checked on google and found some studies like these ones

Repression of Slc24a5 can reduce pigmentation in chicken - PubMed

Slc24a5 is a putative cation transporter, which is a member of the potassium-dependent sodium-calcium ion exchanger family. Association of the Slc24a5 gene with pigmentation has been established in Zebrafish, mice and humans. Despite these findings, its function in chicken remains unknown. The...

pubmed.ncbi.nlm.nih.gov

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans - PubMed

Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5...

pubmed.ncbi.nlm.nih.gov

Type keywords "SLC24A5 melanin or melanogenesis.
They didn't exact name of the said inhibitor but at least, the process seemed legit. I wanted to try but the product is sold apparently only in Asia and most stores were not in english , i wasn't comfortable buying in an unknown currency. so i backed off.

Now this year i learned about the slc pills and when researching i found out that the main ingredient enzyme SirNA-5 was the one inhibiting this SLC24A5 gene.
If you type the keywords "SiRNA-5 melanin" on google or duckduckgo, you will find many results. Here are some:

Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes - PubMed

Tyrosinase (TYR) plays a critical role in cellular melanogenesis and, thus, has been the major target of pharmacological approaches for the control of skin pigmentation. This study examined an alternative molecular approach using TYR-small interfering RNA (siRNA) to control melanogenesis in the...

pubmed.ncbi.nlm.nih.gov

US20140336371A1 - Sirna molecule for inhibiting growth of melanin and application thereof - Google Patents

Provided is a double-chain siRNA molecule targeting a microphthalmia-associated transcription factor MITF coding gene. A sense strand of the siRNA molecule has a sequence of SEQ ID NO: 3 and an anti-sense strand has a sequence of SEQ ID NO: 4, and the anti-sense strand specifically binds to mRNA...

patents.google.com

siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis - PubMed

Cyclooxygenase-2 (COX-2) is an enzyme induced in response to multiple mitogenic and inflammatory stimuli, including UV light. UV-induced COX-2 expression induces production of prostaglandin E2 (PGE2) in keratinocytes, which mediates inflammation and cell proliferation. Until recently, studies...

pubmed.ncbi.nlm.nih.gov

There are many products like this one that are not popular or even known in western countries. But if you dig into the asian google you can find some good stuffs sometimes.
Asian researchers are way more advanced in the subject than their western counterparts and i doubt it will ever be FDA approved. Heck, the FDA even removed its approbation for NAC despite its numerous benefits. Thankfully i don't live in the US and here we still have access to many products.

Thanks so much for these studies.

 

[BiegeCaramel]

Getting this light in 3 years is pretty reasonable imo.

Could be just glutathione shots. Tutsis Rwandese women ( same for the indian and peulhs women ) can be dark skinned but their melanin is very diluted and not very concentrated. This kind of complexion react very well to glutathione ( or even mild topical lighteners) as there isn't that much work to begin.

And glutathione can be used during pregnancy. Watch out for the complexion of her baby when she gives birth. If the baby is very light skinned ( beyond normal), that would mean it's probably glutathione she is using. If the baby is dark skinned like mom and dad, then she is using probably mild topicals.

Actually glutathione CAN increase chances of complications. There's differing opinions on glutathione for pregnant women because it has been shown to cause complications to some (like miscarriage) and also has protective properties for mother and baby. Its a risk not even worth taking and because of that, doctors generally would not advise it as there is no clear understanding.
In addition, i don't believe in gluta IV - Its a gimick which does not have proper scientific backing to whitening the skin, people who do it ALWAYS use topicals also. Its easier to work on people who are already pale to begin with (like kojic acid). I wish we could dead the concept of gluta IV for whitening dark skin. Scientifically, it should but in reality...it really doesn't lol. Great for the immune system though.

I think you're right tho...3 years to get this light is so doable and i'm sure she's using something mild. I'm just wondering what it is because I'm planning to get pregnant in the next year and maannnn that pregnancy PIH...God forbid.

 

[BiegeCaramel]

I just posted some documents i found.

Also, no i'm not afraid to become porcelaine white lol. The process is very gradual and as soon as i hit my goal i will go into maintenance mode. That said, complexion dysmorphia is really a thing because even when i became very light with the product, i still saw myself dark when looking in the mirror and i kept pushing. Its only when i did some pictures comparisons i saw that i had passed my initial goal since at least one month.
I understand why some girls become too white , you don't see yourself lightening. Your eyes get used to your complexion pretty quickly. Just like when you lose weight and you still see yourself overweight.

Anyway, to get back to the theme of the thread, there are many not mainstream actives that can be used to lighten their skin without having to rub creams or glutathione only ( i love glutathion and still use it for anti aging and health purposes but i doubt it can turn a very dark person in Grety Riverson).

This is so true....Sometimes I feel light but then I feel dark in photos...especially next to people of no-colour.

 

[Michoco]

@Temarinette thanx for the studies!

 

[Temarinette]

Actually glutathione CAN increase chances of complications. There's differing opinions on glutathione for pregnant women because it has been shown to cause complications to some (like miscarriage) and also has protective properties for mother and baby. Its a risk not even worth taking and because of that, doctors generally would not advise it as there is no clear understanding.
In addition, i don't believe in gluta IV - Its a gimick which does not have proper scientific backing to whitening the skin, people who do it ALWAYS use topicals also. Its easier to work on people who are already pale to begin with (like kojic acid). I wish we could dead the concept of gluta IV for whitening dark skin. Scientifically, it should but in reality...it really doesn't lol. Great for the immune system though.

I think you're right tho...3 years to get this light is so doable and i'm sure she's using something mild. I'm just wondering what it is because I'm planning to get pregnant in the next year and maannnn that pregnancy PIH...God forbid.

I know some physicians don't recommend glutathione but I have some acquaintances who used glutathione during their pregnancies with no issue and getting light babies and they got no pregnancy mask. So it might be a good idea if the dosage is not too high. After all, glutathione is found in great quantity in vegetables. To forbid glutathione during pregnancy would like saying don't eat vegetables during your pregnancy. I think it's all about the dosage.

The real danger is the vitamin C dosage while taking glutathione. Vitamin C in high dosage is bad during pregnancy. Better stay under 1000 mg or it can trigger complications.



That said, I agree with you that glutathione IV is overrated. The dosage and frequency is not enough to lighten the skin unless once again the user is already light or diluted melanin.

The only glutathione IV I had success with had in its ingredient list a melanin inhibitor. Otherwise, glutathione suppositories worked best. It's more about the repetition than the dosage.

 

[GlossedSkin]

Hi! I've been lurking on and off on sct since 2017, finally decided to join the community after taking interest on this topic.

I got them from a seller in Paris ( France).
I tried it after after a long time friend went very light ( she was lupita Nyongo dark and became like Jasmine Sanders in like 6 months?).

It is not one pill though, but rather a mix of pills.
I took it for 4 months. Side effects, it decreased my appetite and I had some white and blond body hairs randomly on my body but i didn’t mind.
I'm not not too good with estimating shades. Let's say I was brown like a young Gabrielle Union and lightened to a light Rihanna shade ( or like our beloved football player Killian Mbappe).

As i said, it is pretty expensive, at least for me ( I paid like 500€/month). The result was worth it. And when I stopped it took some time to darken and even, I didn't return to my former complexion. The seller said that it was cutting off the melanin production hence the fast lightening.
I searched for a cheaper option on the internet but couldn't find anything lol.

I don't know if this is this exact product the American celebrities are using but the results was fabulous.
I'm sure it is not glutathione alone that lighten the celebrities skin, I've used glutathione for many years on and off and although I got light, it wasn't dramatic ( went from NW50 to NC45 maximum) and I had the impression that i hit a plateau at some time. Had to use topicals to get a more pronounced lightening.
I imagine, they have a regimen easy to follow and many celebrities drink, do drugs or other questionable substances and always partying and it is not compatible with glutathione use ( I had to stop smoking in order for my glutathione regimen to work).

I will try to find some before after pics to post here from my slc pills era.

You said you went from young Gabrielle Union to a light Rihanna shade and never returned to your former shade, I'm curious to ask what shade did your skin stop at after discontinuing the pills?



Also, thank you Temarinette and Michoco for sharing this information about SLC pills! Had you not mentioned it, I and a lot of others still wouldn't know about them.

 

[Temarinette]

Hi! I've been lurking on and off on sct since 2017, finally decided to join the community after taking interest on this topic.




You said you went from young Gabrielle Union to a light Rihanna shade and never returned to your former shade, I'm curious to ask what shade did your skin stop at after discontinuing the pills?



Also, thank you Temarinette and Michoco for sharing this information about SLC pills! Had you not mentioned it, I and a lot of others still wouldn't know about them.

I'm sorry, I think I used the wrong words. Bear with me. English is not my first language.

I darkened after I stopped using it. Just I didn't went back to my original complexion. It's like, my melanin became diluted or something like that. It wasn't as dense as when I started using the pills. That said right I'm just using glutathione and my complexion is in between. I don't lighten but I don't darken either. It does help I think.

You re welcome. Thanks to Michoco who brought out the subject. I wanted previously to start a thread about it but I know how SCT can be sometimes with new products so I was waiting that someone else mentions it to chime in lol.

 

[GlossedSkin]

I'm sorry, I think I used the wrong words. Bear with me. English is not my first language.



I darkened after I stopped using it. Just I didn't went back to my original complexion. It's like, my melanin became diluted or something like that. It wasn't as dense as when I started using the pills. That said right I'm just using glutathione and my complexion is in between. I don't lighten but I don't darken either. It does help I think.



You re welcome. Thanks to Michoco who brought out the subject. I wanted previously to start a thread about it but I know how SCT can be sometimes with new products so I was waiting that someone else mentions it to chime in lol.

Your english is perfect! I understood clearly what you meant in your original post. I think it was me who was not clear enough by what I meant. I was trying to ask what your current complexion is right now since you've mentioned how you've redarkened but didn't go back to your original tone.

 

[Temarinette]

Your english is perfect! I understood clearly what you meant in your original post. I think it was me who was not clear enough by what I meant. I was trying to ask what your current complexion is right now since you've mentioned how you've redarkened but didn't go back to your original tone.

Oh OK, no worry.
Here are again my pictures. First one is i how I looked before last July. The middle one is the max I got. It was in October, i stopped by then. The right one is how I look now in december.

 

[GlossedSkin]

Oh OK, no worry.
Here are again my pictures. First one is i how I looked before last July. The middle one is the max I got. It was in October, i stopped by then. The right one is how I look now in december.

http://imgur.com/a/PEXs9cP

Your results look nice! I can see what you mean by the pills diluting your melanin. Thank you for sharing!

 

[kweeny]

Very interesting thread!
I am very daring but I am scared to try this product.
I will be going back on glutathione. If anyone is sceptical, glutathione works especially when combined with vitamin C, Nac and milk thistle( silymarin) .
Adding MSM is the icing on the cake.
You hands , feet and lips will lighten up well too.

 

[AstronikS]

Ahh, this post pulled me out from my lurker mode lol. I know this one. Even tried it. Got it from a friend. It made me very light, more than glutathione shots did. They are very expensive tho. Couldn't keep up.

So is SLC24A5 an injectable or pill, the Google results shows it’s taken through iv. Do you have any photos of the product? Thanks.

 

[Beleza Carioca]

Very interesting thread!
I am very daring but I am scared to try this product.
I will be going back on glutathione. If anyone is sceptical, glutathione works especially when combined with vitamin C, Nac and milk thistle( silymarin) .
Adding MSM is the icing on the cake.
You hands , feet and lips will lighten up well too.

Can you tell me why you’re scared to try the SLC tablet ?

 

[kweeny]

Can you tell me why you’re scared to try the SLC tablet ?

I am a bit worried about “ it’s method of operation”
It’s a synthetic gene, to simplify things so I am just wondering if it may impact other genetic “ materials “ since the skin literally covers the entire body.
What I am saying is there are documents online that tell us what it is but no studies have been carried out , no side effects recorded, what to expect in the next 5 years etc

See skin lightening is generally risky but anything that alters my gene......

PS - this is my opinion and I genuinely appreciate everyone sharing information about SLC