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Arbutin
Arbutin, which is the b-D-glucopyranoside derivative of hydroquinone, is a naturally occurring plant derived compound that has been used for postinflammatory hyperpigmentation.[13] It is effective in the treatment of disorders of hyperpigmentation characterized by hyperactive melanocytes.[13] The action of arbutin is dependent on its concentration. Higher concentrations are more efficacious than lower concentrations, but they may also result in a paradoxical hyperpigmentation.[13] In comparative in vitro studies of various compounds used to improve the appearance of disorders of hyperpigmentation, arbutin was found to be less toxic than hydroquinone. A dose-dependent reduction in tyrosinase activity, as well as melanin content in melanocytes, was also demonstrated



above what % arbutin would hyperpigmentation or paradox darkening be a risk??
 

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Good question, I was wondering about arbutin myself...is it really as effective as the claims make it out to be???
I think sepiwhite would be a good alternative..any thoughts???

G
 

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Arbutin
Arbutin, which is the b-D-glucopyranoside derivative of hydroquinone, is a naturally occurring plant derived compound that has been used for postinflammatory hyperpigmentation.[13] It is effective in the treatment of disorders of hyperpigmentation characterized by hyperactive melanocytes.[13] The action of arbutin is dependent on its concentration. Higher concentrations are more efficacious than lower concentrations, but they may also result in a paradoxical hyperpigmentation.[13] In comparative in vitro studies of various compounds used to improve the appearance of disorders of hyperpigmentation, arbutin was found to be less toxic than hydroquinone. A dose-dependent reduction in tyrosinase activity, as well as melanin content in melanocytes, was also demonstrated



above what % arbutin would hyperpigmentation or paradox darkening be a risk??
I use arb at 10% but this is beta, so isnt as 'pure' as alpha. It works, but I use the same precautions as I do with HQ (using sunblock etc) Shame we cant get hold of the deoxy easily. Does anyone know if sepiwhite is patented?
 
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